Peptide Therapy Comparison
All 23 peptides compared side by side — FDA status, monthly pricing, timelines, and clinical evidence. Find the right fit before you consult.
Compare · Last updated March 2026 · Prices reflect US telehealth averages
Full Comparison Table
Scroll horizontally to see all columns. Sorted by our composite ranking score.
| Peptide | Category | FDA Status | Monthly Cost | Timeline | Top Benefit |
|---|---|---|---|---|---|
| Semaglutide | Weight Management | FDA Approved | $300–$500 | Moderate (4–8 wk) | 15-20% body weight reduction |
| Tirzepatide | Weight Management | FDA Approved | $400–$700 | Moderate (4–8 wk) | Up to 22.5% weight loss |
| BPC-157 | Recovery & Healing | Category 2 | $100–$200 | Fast (1–4 wk) | Accelerated tissue healing |
| CJC-1295 / Ipamorelin | Growth Hormone | Compoundable | $200–$400 | Moderate (4–8 wk) | Increased growth hormone |
| PT-141 | Sexual Health | FDA Approved | $200–$400 | Fast (1–4 wk) | Increased sexual desire |
| Retatrutide | Weight Management | Under Review | $500–$800 | Moderate (4–8 wk) | Up to 24% weight loss |
| Liraglutide | Weight Management | FDA Approved | $200–$400 | Moderate (4–8 wk) | Clinically proven weight loss |
| Tesamorelin | Weight Management | FDA Approved | $250–$450 | Moderate (4–8 wk) | Visceral fat reduction |
| TB-500 | Recovery & Healing | Category 2 | $150–$300 | Moderate (4–8 wk) | Tissue regeneration |
| AOD-9604 | Weight Management | Category 2 | $100–$200 | Moderate (4–8 wk) | Targeted fat loss |
| KPV | Recovery & Healing | Research Stage | $80–$180 | Moderate (4–8 wk) | Gut barrier repair |
| Ipamorelin | Growth Hormone | Compoundable | $120–$250 | Moderate (4–8 wk) | Gentle GH boost |
| Sermorelin | Growth Hormone | Compoundable | $200–$350 | Slow (8–12+ wk) | Natural GH stimulation |
| GHK-Cu | Anti-Aging & Skin | Compoundable | $80–$180 | Slow (8–12+ wk) | Collagen production |
| NAD+ | Longevity & Energy | Compoundable | $400–$800 | Fast (1–4 wk) | Cellular energy production |
| Melanotan II | Tanning & Libido | Research Stage | $60–$150 | Fast (1–4 wk) | Skin tanning without UV exposure |
| Selank | Cognitive & Mood | Category 2 | $80–$160 | Fast (1–4 wk) | Anxiety reduction |
| Semax | Cognitive & Mood | Research Stage | $80–$160 | Fast (1–4 wk) | Enhanced focus and concentration |
| DSIP | Sleep & Recovery | Category 2 | $80–$160 | Fast (1–4 wk) | Deep sleep promotion |
| MOTS-c | Metabolic & Exercise | Research Stage | $200–$400 | Moderate (4–8 wk) | Exercise-mimetic effects |
| Epithalon | Anti-Aging & Longevity | Category 2 | $150–$300 | Slow (8–12+ wk) | Telomerase activation |
| Dihexa | Cognitive Enhancement | Research Stage | $150–$300 | Moderate (4–8 wk) | Neurogenesis |
| Thymosin Alpha-1 | Immune Support | Category 2 | $200–$400 | Slow (8–12+ wk) | Enhanced T-cell function |
Peptide-by-Peptide Breakdown
Detailed profiles for all 23 peptides in our database.
Semaglutide
Weight Management
FDA-approved GLP-1 receptor agonist for significant weight loss and metabolic improvement.
Benefits
- 15-20% body weight reduction
- Appetite suppression
- Blood sugar control
- Cardiovascular benefits
Side Effects
Nausea, Diarrhea, Constipation
Tirzepatide
Weight Management
Dual-action peptide targeting both GIP and GLP-1 receptors. Outperforms semaglutide in clinical trials.
Benefits
- Up to 22.5% weight loss
- Dual hormone action
- Improved insulin sensitivity
- Superior efficacy
Side Effects
Nausea, Diarrhea, Injection site reactions
BPC-157
Recovery & Healing
Gastric peptide that accelerates healing of muscles, tendons, ligaments, and gut lining.
Benefits
- Accelerated tissue healing
- Gut lining repair
- Anti-inflammatory
- Joint pain relief
Side Effects
Nausea (rare), Dizziness (rare)
CJC-1295 / Ipamorelin
Growth Hormone
Popular growth hormone secretagogue combo that boosts natural GH for anti-aging, body composition, and recovery.
Benefits
- Increased growth hormone
- Better body composition
- Improved sleep
- Enhanced recovery
Side Effects
Flushing, Headache, Water retention, Tingling
PT-141
Sexual Health
FDA-approved for sexual desire disorder. Works via the CNS to improve desire and arousal.
Benefits
- Increased sexual desire
- Improved arousal
- Works for both sexes
- CNS-mediated
Side Effects
Nausea, Flushing, Headache
Retatrutide
Weight Management
Next-generation triple agonist (GLP-1/GIP/Glucagon) showing up to 24% weight loss in trials.
Benefits
- Up to 24% weight loss
- Triple hormone action
- Metabolic reset
- Emerging research
Side Effects
Nausea, Diarrhea, Decreased appetite
Liraglutide
Weight Management
FDA-approved GLP-1 receptor agonist for weight management. The first GLP-1 with generic availability, offering a more affordable entry point.
Benefits
- Clinically proven weight loss
- Appetite suppression
- Blood sugar regulation
- Generic availability (lower cost)
Side Effects
Nausea, Gastrointestinal issues, Headache, Gallbladder problems (rare)
Tesamorelin
Weight Management
FDA-approved GHRH analog that selectively reduces visceral fat. Also supports lean mass and metabolic health.
Benefits
- Visceral fat reduction
- Lean mass support
- Metabolic improvement
- Hepatic fat reduction
Side Effects
Injection site reactions, Joint pain, Peripheral edema
TB-500
Recovery & Healing
Promotes tissue repair, reduces inflammation, and improves flexibility. Often stacked with BPC-157.
Benefits
- Tissue regeneration
- Reduced inflammation
- Improved flexibility
- Wound healing
Side Effects
Headache, Nausea, Lightheadedness
AOD-9604
Weight Management
Modified HGH fragment that targets fat burning without growth effects. Specifically targets abdominal fat.
Benefits
- Targeted fat loss
- No blood sugar impact
- Stimulates lipolysis
- Safe profile
Side Effects
Injection site pain, Headache (rare)
KPV
Recovery & Healing
Short tripeptide derived from alpha-MSH with potent anti-inflammatory and gut-healing properties.
Benefits
- Gut barrier repair
- Anti-inflammatory
- IBD support
- Skin barrier health
Side Effects
Mild GI discomfort (rare)
Ipamorelin
Growth Hormone
Gentle growth hormone secretagogue with minimal side effects. Great entry point for GH optimization.
Benefits
- Gentle GH boost
- Improved sleep
- Fat loss support
- Minimal side effects
Side Effects
Headache (rare), Mild hunger
Sermorelin
Growth Hormone
GHRH analog that stimulates natural GH production. Gentler alternative to direct GH therapy.
Benefits
- Natural GH stimulation
- Improved body composition
- Better sleep
- Anti-aging
Side Effects
Injection site reactions, Flushing, Dizziness
GHK-Cu
Anti-Aging & Skin
Naturally occurring copper peptide that stimulates collagen, repairs skin, and has potent antioxidant effects.
Benefits
- Collagen production
- Skin rejuvenation
- Wound healing
- Hair growth
Side Effects
Skin irritation (topical), Redness
NAD+
Longevity & Energy
Essential coenzyme for cellular energy and DNA repair. Levels decline with age, making supplementation popular for longevity.
Benefits
- Cellular energy production
- DNA repair
- Anti-aging
- Mental clarity
Side Effects
Nausea during infusion, Flushing, Discomfort
Melanotan II
Tanning & Libido
Synthetic melanocortin peptide that stimulates melanin production for tanning and has libido-enhancing effects.
Benefits
- Skin tanning without UV exposure
- Libido enhancement
- Appetite suppression
- Skin protection
Side Effects
Nausea, Facial flushing, Mole darkening, Appetite changes
Selank
Cognitive & Mood
Synthetic anxiolytic peptide with nootropic effects. Reduces anxiety without sedation.
Benefits
- Anxiety reduction
- Improved focus
- Enhanced memory
- Immune modulation
Side Effects
Fatigue (rare), Nasal irritation
Semax
Cognitive & Mood
Synthetic peptide derived from ACTH with potent nootropic and neuroprotective effects. Widely used for focus and cognitive enhancement.
Benefits
- Enhanced focus and concentration
- Neuroprotection
- Memory improvement
- BDNF stimulation
Side Effects
Nasal irritation, Mild headache (rare)
DSIP
Sleep & Recovery
Neuropeptide that promotes deep delta wave sleep. Normalizes circadian rhythm without grogginess.
Benefits
- Deep sleep promotion
- Circadian normalization
- Stress reduction
- No grogginess
Side Effects
Headache (rare), Vivid dreams
MOTS-c
Metabolic & Exercise
Mitochondrial-derived peptide that mimics exercise effects. Improves metabolic function and insulin sensitivity.
Benefits
- Exercise-mimetic effects
- Improved metabolism
- Insulin sensitivity
- Fat oxidation
Side Effects
Injection site reactions, Mild fatigue
Epithalon
Anti-Aging & Longevity
Synthetic tetrapeptide studied for telomerase activation and telomere lengthening. One of the most researched anti-aging peptides.
Benefits
- Telomerase activation
- Cellular renewal and longevity
- Sleep quality improvement
- Potential tumor suppression
Side Effects
Injection site irritation, Limited long-term human safety data
Dihexa
Cognitive Enhancement
Potent cognitive-enhancing peptide that promotes neurogenesis and synaptic plasticity via the HGF/c-Met pathway.
Benefits
- Neurogenesis
- Synaptic plasticity
- Memory enhancement
- Cognitive repair
Side Effects
Mild headache, Sleep disturbance at high doses, Over-stimulation
Thymosin Alpha-1
Immune Support
Thymic peptide that enhances T-cell function and immune response. Used for chronic infections and immune support.
Benefits
- Enhanced T-cell function
- Improved immunity
- Anti-inflammatory
- Chronic infection support
Side Effects
Injection site reactions, Mild fatigue
Our Verdict
Top picks by category — based on clinical evidence, safety, and value.
Semaglutide
Weight Management
FDA-approved, clinically proven 15–20% weight reduction. The gold standard.
BPC-157
Recovery & Healing
Accelerates healing of muscles, tendons, gut lining. Fast-acting, affordable.
CJC-1295 / Ipamorelin
Growth Hormone
The cornerstone GH secretagogue stack for body composition, sleep, and longevity.
DSIP
Sleep & Recovery
Promotes natural delta-wave sleep without grogginess. Fast results, budget-friendly.
Selank
Cognitive & Mood
Reduces anxiety without sedation. Nootropic effects improve focus and memory.
AOD-9604
Weight Management
Targeted fat loss at $100–200/mo. Modified GH fragment with a clean safety profile.
Comparison
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